Thyroid Support provides iodine, selenium, zinc, vitamin A, riboflavin, trace minerals, N‑acetyl‑L‑tyrosine, American ginseng, and Coleus forskohlii at doses designed to support thyroid hormone production, immune balance, and metabolic/energy pathways in a multi‑nutrient matrix. Note: Individual ingredient RCTs typically evaluate single agents at higher doses than in multi‑ingredient formulas.[ppl-ai-file-upload.s3.amazonaws]
These studies explore outcomes related to individual ingredients used in Thyroid Support. Research on individual ingredients does not necessarily reflect the effect of the full formula. When study doses differ from Thyroid Support, we note it. Not intended to diagnose, treat, cure, or prevent any disease.
Iodine (100 µg/day as potassium iodide)
Studied for: correction of mild iodine deficiency with reductions in serum thyroglobulin and thyroid volume, improvement in iodine status, and benefits for cognition in iodine‑deficient populations.academic.oup+3
Dose note: Adult RCTs commonly use about 150–200 µg/day; formula provides 100 µg/day as foundational support in combination with other thyroid cofactors.pubmed.ncbi.nlm.nih+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
Randomized trial in mildly iodine‑deficient adults (150 µg/day, 24 weeks): Journal of Clinical Endocrinology & Metabolism[academic.oup]
Association of mild–moderate iodine deficiency with thyroid volume/function: JAMA Network Open[binasss.sa]
Iodine repletion and cognition in deficiency: ScienceDirect[sciencedirect]
Selenium (50 µg/day as selenomethionine)
Studied for: reductions in TSH and thyroid peroxidase antibodies (TPOAb), improvements in oxidative‑stress markers, and better ultrasound echogenicity in Hashimoto thyroiditis in multiple RCTs and meta‑analyses.pmc.ncbi.nlm.nih+2
Dose note: Trials generally use 80–300 µg/day; Thyroid Support provides 50 µg/day for ongoing immune and antioxidant support alongside other micronutrients.pmc.ncbi.nlm.nih+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
Systematic review/meta‑analysis of 35 RCTs in Hashimoto thyroiditis: Thyroid (Mary Ann Liebert)[liebertpub]
Detailed open‑access meta‑analysis: PMC[pmc.ncbi.nlm.nih]
Review on selenium and thyroid disease: PMC[pmc.ncbi.nlm.nih]
Zinc (25 mg/day as TRAACS zinc bisglycinate)
Studied for: associations between zinc deficiency and hypothyroidism‑like symptoms, low FT3/FT4, and case reports/series where zinc repletion improved thyroid function and dermatologic findings.pmc.ncbi.nlm.nih+2
Dose note: Clinical reports use a range of 10–30 mg/day; formula provides 25 mg/day in a chelated form to support thyroid hormone metabolism and immune function.sciencedirect+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
Case series on zinc deficiency associated with hypothyroidism: PMC[pmc.ncbi.nlm.nih]
Study on zinc status and thyroid hormones: ScienceDirect[sciencedirect]
Review of low zinc intake and thyroid/metabolic rate: ScienceDirect[sciencedirect]
Vitamin A (600 µg RAE/day as retinyl palmitate)
Studied for: modulation of pituitary–thyroid axis, reduced goiter and TSH, and improved T3 levels in vitamin‑A‑deficient, iodine‑insufficient populations.pubmed.ncbi.nlm.nih+2
Dose note: Human interventions often use higher therapeutic doses; Thyroid Support provides 600 µg RAE/day as ongoing support within safe daily intake ranges.pmc.ncbi.nlm.nih+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
Narrative mini‑review on vitamin A and thyroid disorders: PubMed[pubmed.ncbi.nlm.nih]
Relationship of vitamin A and thyroid function in obesity: Frontiers in Nutrition[frontiersin]
Riboflavin (5 mg/day as riboflavin‑5‑phosphate)
Studied for: altered riboflavin metabolism and glutathione‑reductase activity in hypothyroid adults, with normalization after thyroxine therapy, highlighting its role as an energy/redox cofactor in thyroid states.journals.sagepub+2
Dose note: Classic mechanistic studies focus on riboflavin status rather than high‑dose supplementation; formula provides 5 mg/day (well above RDA) in active form to support flavoprotein‑dependent pathways.[ppl-ai-file-upload.s3.amazonaws][journals.sagepub]
Further reading:
Riboflavin metabolism in hypothyroid adults: PubMed[pubmed.ncbi.nlm.nih]
Copper (0.5 mg/day as TRAACS copper bisglycinate) and Manganese (5 mg/day as TRAACS manganese bisglycinate)
Studied for: roles in thyroid hormone homeostasis and oxidoreductive balance; experimental and epidemiologic data link altered copper and manganese levels with changes in TSH, T4/T3 and indices of thyroid hormone resistance, as well as antioxidant enzyme activity (Cu/Zn‑SOD, Mn‑SOD).pmc.ncbi.nlm.nih+4
Dose note: Human data involve both deficiency and excess states; Thyroid Support uses physiological doses under upper limits to provide cofactor support for antioxidant enzymes involved in thyroid hormone synthesis.pmc.ncbi.nlm.nih+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
Review on trace elements and thyroid oxidoreductive homeostasis: PMC[pmc.ncbi.nlm.nih]
Study on multiple blood metals and thyroid function in adults: Frontiers in Endocrinology[frontiersin]
Chromium (50 µg/day as chromium nicotinate glycinate)
Studied for: improved insulin sensitivity, glycemic control, and attenuation of weight/fat‑mass gain in type 2 diabetes with 600–1,000 µg/day chromium picolinate in randomized double‑blind trials.diabetesjournals+2
Dose note: Clinical trials use substantially higher intakes; Thyroid Support provides 50 µg/day as a metabolic cofactor for patients with thyroid‑related weight and glucose concerns.sciencedirect+1[ppl-ai-file-upload.s3.amazonaws]
Further reading:
RCT in type 2 diabetes (1,000 µg/day chromium picolinate): Diabetes Care[diabetesjournals]
Systematic review/meta‑analysis on chromium and glycemia: PMC[pmc.ncbi.nlm.nih]
N‑Acetyl‑L‑Tyrosine (200 mg/day)
Studied for: in animal models, L‑tyrosine supplementation increases T3/T4 and improves neuroendocrine function under chronic stress; N‑acetyl‑L‑tyrosine has been identified as a signaling molecule triggering mitohormetic, cytoprotective responses.pmc.ncbi.nlm.nih+1
Dose note: Experimental work uses higher per‑kg dosing; formula provides 200 mg/day as a well‑tolerated substrate and stress‑axis support in combination with iodine and micronutrients.[pmc.ncbi.nlm.nih][ppl-ai-file-upload.s3.amazonaws]
Further reading:
Tyrosine and neuroendocrine function under chronic stress (mouse model): PMC[pmc.ncbi.nlm.nih]
N‑acetyl‑L‑tyrosine as a mitohormesis trigger: PMC[pmc.ncbi.nlm.nih]
American Ginseng (Panax quinquefolius, 200 mg/day, standardized to 5% ginsenosides)
Studied for: reductions in cancer‑related fatigue scores and improvements in general and physical fatigue in a phase III, multicenter, randomized, double‑blind trial using 2,000 mg/day in cancer patients (N07C2), with good safety profile.ncbi.nlm.nih+2
Dose note: RCTs typically use 1,000–2,000 mg/day; Thyroid Support provides 200 mg/day as part of a broader matrix targeting fatigue and stress resilience common in thyroid‑related complaints.[ascopubs][ppl-ai-file-upload.s3.amazonaws]
Further reading:
N07C2 phase III RCT (2,000 mg/day, 8 weeks): PMC[ncbi.nlm.nih]
ASCO abstract of the trial: ASCO Journals[ascopubs]
Coleus forskohlii (50 mg/day, standardized to 20% forskolin ≈10 mg) Studied for: favorable changes in body composition (reduced body fat, increased lean mass or attenuated fat gain) in overweight/obese adults in 12‑week randomized, double‑blind, placebo‑controlled trials with 250 mg of 10% forskolin extract twice daily; mechanistic work shows forskolin directly stimulates thyroid hormone secretion and cAMP‑mediated thermogenic pathways.pmc.ncbi.nlm.nih+3 Dose note: Human trials typically use 500 mg/day of 10% extract (≈50 mg forskolin); Thyroid Support provides 50 mg/day of 20% extract (≈10 mg forskolin) as a metabolic cofactor layered with thyroid‑nutrient support.pubmed.ncbi.nlm.nih+1[ppl-ai-file-upload.s3.amazonaws] Further reading: RCT in overweight/obese men (25 mg forskolin BID, 12 weeks): PMC[pmc.ncbi.nlm.nih] Forskolin stimulation of T3/T4 secretion (in vitro): PubMed[pubmed.ncbi.nlm.nih] Thyroidal effects of forskolin in experimental models: J‑Stage PDF[jstage.jst.go]
