What the Research Shows: Clinical Evidence Summary
Adrenal Calm provides L-theanine, phosphatidylserine, and synergistic botanicals/nutrients at doses contributing to a multi-pathway stress and sleep support matrix. Note: Individual ingredient RCTs typically evaluate single agents at higher doses than in multi-ingredient formulas.
*These studies explore outcomes related to individual ingredients used in Adrenal Calm. Research on individual ingredients does not necessarily reflect the effect of the full formula. When study doses differ from Adrenal Calm, we note it. Not intended to diagnose, treat, cure, or prevent any disease.
L-Theanine (200 mg/serving)
Studied for: improved sleep quality (latency, efficiency, refreshment), reduced stress-related symptoms, and alpha-wave relaxation in healthy adults (systematic review of 13 RCTs).[pubmed.ncbi.nlm.nih]
Dose note: RCTs typically 200–450 mg/day. Formula: 200 mg/serving – directly aligned. (PubMed)
Further reading:
Systematic review (2026, 13 trials): PubMed
Hidese et al., 2019 (RCT): PMC
Theanine sleep quality RCT (young women): RSC Publishing
Ashwagandha Root Extract (100 mg/serving, 1.5% withanolides)
Studied for: serum cortisol reductions, PSS/perceived stress, anxiety scales, and sleep quality in stressed adults (23-trial systematic review).thieme-connect+1
Dose note: RCTs typically 240–600 mg/day extract. Formula: 100 mg/serving in blend. (Thieme Connect)
Further reading:
Systematic review (2026, hormonal modulation): Thieme Connect
Lopresti et al., 2019 (RCT): PMC
NIH fact sheet (2026): ODS
Phosphatidylserine (50 mg/serving from sunflower)
Studied for: blunted cortisol/ACTH responses to acute exercise/psychosocial stress in healthy adults (multiple RCTs).pmc.ncbi.nlm.nih+1
Dose note: Trials use 300–800 mg/day. Formula: 50 mg/serving as targeted support. (PMC)
Further reading:
Nerozzi et al., 2008 (exercise stress RCT): PMC
Hellhammer review: ZRT Lab
Lemon Balm Leaf Extract (100 mg/serving, 3% rosmarinic acid)
Studied for: anxiety reduction, sleep quality (insomnia scores), and acute stress response in adults.pmc.ncbi.nlm.nih+1
Further reading:
Cyracos extract trial (15 days): PMC
Cases et al., 2011 (pilot RCT): PMC
Clinical review (2024): PMC
Passionflower Flower Extract (100 mg/serving, 3.5% flavonoids)
Studied for: subjective sleep quality, perceived stress, and total sleep time in adults with sleep/stress issues (RCT).pmc.ncbi.nlm.nih+1
Further reading:
SIVI extract RCT (2024, 30 days): PMC
Ngan et al., 2011 (tea RCT): Wiley
Neuropsychiatric review: PMC
Valerian Root Extract (100 mg/serving, 0.8% valerenic acid)
Studied for: subjective sleep improvements (latency, quality) in insomnia; meta-analyses show modest benefits after 2+ weeks.pmc.ncbi.nlm.nih+1
Dose note: Trials use 400–900 mg/day. Formula: 100 mg/serving in blend. (PMC)
Further reading:
Bent review/meta-analysis: PMC
Meta-analysis (2010): ScienceDirect
Magnesium (as Di-Magnesium Malate, 75 mg elemental/serving)
Studied for: sleep efficiency, onset latency, cortisol/melatonin normalization in older adults with insomnia (double-blind RCT).pubmed.ncbi.nlm.nih+1
Dose note: Trials use 300–500 mg/day. Formula: 75 mg/serving as foundational support. (PMC)
Further reading:
Abbasi RCT (elderly insomnia): PMC
Review (2021): PubMed
Activated B Vitamins (B1 50 mg, B2 10 mg, B6 5 mg, B12 2,000 mcg methylcobalamin, Pantothenic Acid 75 mg/serving)
Studied for: mood/stress improvements, reduced fatigue in high-stress populations (B-complex RCTs/meta-analyses).consensus+1
Further reading:
Stough et al., 2011 (33-day RCT): PMC
Meta-analysis (fatigue): IJBR
Vitamin C (as Ascorbic Acid, 100 mg/serving) + Taurine (300 mg/serving) Studied for: Vitamin C – attenuated cortisol in acute stress (high-dose RCTs); Taurine – GABAergic relaxation/sleep support (mechanistic/case data).drkumardiscovery+1 Dose note: Vitamin C trials 1,000+ mg/day; Taurine 1,000+ mg in cases. Formula provides foundational doses. Further reading: Magnesium/Vit C fatigue RCT: PMC
Taurine sleep case: Enticare