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B-Active Plus
B-Active Plus
B-Active Plus
B-Active Plus
B-Active Plus
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B-Active Plus

$15.95
$15.95 $15.95

B-Active Plus is a daily, high-potency B-complex designed to support cellular energy production, healthy methylation, and balanced mood using coenzymated B vitamins and targeted methyl-donor nutrients so you can feel clear, steady, and supported through every phase of life.

Supports energy metabolism, premenstrual mood balance, and stress resilience.

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B-Active Plus

$15.95
$15.95 $15.95

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Key highlights
  • Supports cellular energy production
  • Supports healthy methylation and homocysteine metabolism
  • Supports mood balance and stress resilience
  • Supports healthy estrogen metabolism pathways
  • Supports liver and detoxification processes
  • Supports cognitive clarity and focus

How to use

Serving size: 1 capsule
Servings per container: 30

Suggested use: Take 1 capsule daily in the morning with food and water.

Optional routine:

  • If sensitive, start with 1 capsule every other day for 3–5 days, then increase to daily use.
  • Avoid taking late in the evening, as B vitamins may be energizing for some individuals.

Ingredients

Key ingredients:

  • Vitamin B6 (as pyridoxal-5-phosphate)
  • Riboflavin (as riboflavin-5-phosphate)
  • Folate (as L-5-methyltetrahydrofolate)
  • Vitamin B12 (as methylcobalamin)
  • Betaine anhydrous (TMG)
  • Choline (as choline bitartrate)
  • Pantothenic acid
  • Biotin

Want full details? Scroll down for the full Supplement Facts panel, ingredient-by-ingredient breakdown, and research highlights.

Other ingredients: Hypromellose (capsule), silica, calcium silicate, magnesium silicate, magnesium stearate, microcrystalline cellulose.

Shipping & returns

If you’re looking to return or exchange your order for whatever reason, we're here to help! We offer free returns within 30 days of purchase.

You can return your product for store credit, a different product, or a refund to the original payment method.
B-Active Plus
B-Active Plus

Size: 30 Capsules

B-Active Plus
B-Active Plus
B-Active Plus
B-Active Plus
B-Active Plus

Why you'll love it

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Practitioner-Strength, Activated Forms

Formulated with coenzymated B vitamins, including riboflavin-5-phosphate, pyridoxal-5-phosphate, methylcobalamin, and L-5-MTHF for direct participation in key metabolic pathways.

Daily Energy + Mood Support

Supports healthy energy production, neurotransmitter balance, and methylation pathways involved in hormone metabolism so you can feel focused and steady throughout your day.

Simple, Foundational Support

One capsule daily makes it easy to support foundational pathways involved in stress response, hormone processing, and metabolic balance. Ideal for stacking with other protocols.

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30

(Insert Supplement Facts image: file_000000003c20722f9a7d30730e53403f)

Per 1 Capsule:

Thiamin (as thiamin HCl) – 50 mg
Riboflavin (as riboflavin-5-phosphate) – 20 mg
Niacin (as niacinamide) – 50 mg
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate) – 50 mg
Folate (as L-5-methyltetrahydrofolate calcium) – 340 mcg DFE
Vitamin B12 (as methylcobalamin) – 150 mcg
Biotin – 1,000 mcg
Pantothenic acid (as D-calcium pantothenate) – 125 mg
Choline (as choline L(+) bitartrate) – 50 mg
Betaine anhydrous (trimethylglycine) – 200 mg

Other ingredients: Hypromellose, silica, calcium silicate, magnesium silicate, magnesium stearate, microcrystalline cellulose.

Key Ingredients

Vitamin B6 (as Pyridoxal-5-Phosphate)

Supports mood balance and healthy hormone-related symptoms.

Learn More

Vitamin B6 (as Pyridoxal-5-Phosphate)

Pyridoxal-5-phosphate is the active coenzyme form of vitamin B6. It is required for neurotransmitter production, amino acid metabolism, and homocysteine transsulfuration. Clinical studies have evaluated B6 for support of premenstrual mood symptoms and overall well-being. It is included here at practitioner-level dosing to support mood and methylation pathways.

Folate (as L-5-Methyltetrahydrofolate) + Vitamin B12 (as Methylcobalamin)

Supports methylation and healthy homocysteine metabolism.

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Folate (as L-5-Methyltetrahydrofolate) + Vitamin B12 (as Methylcobalamin)

L-5-MTHF is the bioactive form of folate, and methylcobalamin is an active form of vitamin B12. Together, they donate methyl groups required for the conversion of homocysteine to methionine and support production of SAMe, the body’s universal methyl donor. Healthy methylation supports neurotransmitter balance, cellular repair, and hormone metabolism. This formula uses active forms to directly participate in these pathways.

Riboflavin (as Riboflavin-5-Phosphate)

Supports energy metabolism and B-vitamin activation.

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Riboflavin (as Riboflavin-5-Phosphate)

Riboflavin-5-phosphate is the active coenzyme form of vitamin B2. It functions in redox reactions and supports enzymes involved in folate and B6 metabolism. Adequate riboflavin status supports mitochondrial energy production and healthy methylation recycling. It is included to optimize synergy among the B vitamins.

Betaine Anhydrous (Trimethylglycine)

Supports methyl donation and homocysteine balance.

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Betaine Anhydrous (Trimethylglycine)

Betaine is a methyl donor derived from choline. It supports the BHMT pathway, an alternative route for remethylating homocysteine. Research shows betaine contributes to healthy methylation status and complements folate-dependent pathways. It is included to provide comprehensive methyl-donor support.

Choline (as Choline Bitartrate)

Supports liver and hormone metabolism.

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Choline (as Choline Bitartrate)

Choline is an essential nutrient involved in phospholipid synthesis and methyl metabolism. It supports normal liver function and contributes to the body’s methyl pool via conversion to betaine. Adequate choline intake is especially important for women during times of increased hormonal demand. It is included to support liver-mediated hormone processing.

Pantothenic Acid (Vitamin B5)

Supports adrenal and energy pathways.

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Pantothenic Acid (Vitamin B5)

Pantothenic acid is required for synthesis of coenzyme A, a critical molecule in fatty acid metabolism and steroid hormone synthesis. It supports cellular energy production and healthy stress response pathways. It is included at high potency to support metabolic resilience.

See More Ingredients
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Why Dr. Brighten Recommends It

Modern life increases demand on methylation, stress response, and energy pathways. Many women are navigating high stress, fluctuating hormones, and nutrient gaps that impact how they feel day to day.

I formulated B-Active Plus around three priorities:

  1. Comprehensive methylation support
  2. Practitioner-strength mood and stress support
  3. Foundational energy metabolism support

I recommend B-Active Plus for women who want support with low energy, premenstrual mood changes, and increased stress demands, especially during high-output seasons of life.

Ask a clinician first if you are pregnant, nursing, trying to conceive, taking medications, or managing a medical condition.

Research Shows

What the Research Shows: Clinical Evidence Summary

B-Active Plus provides coenzymated B vitamins (riboflavin-5-phosphate, pyridoxal-5-phosphate, methylcobalamin, L-5-methyltetrahydrofolate), biotin, pantothenic acid, choline bitartrate, and betaine anhydrous (TMG) at practitioner-strength doses supporting methylation and energy metabolism. Note: Individual ingredient RCTs typically evaluate single agents or simpler B-complexes at similar or higher doses than in multi-nutrient formulas.

*These studies explore outcomes related to individual ingredients used in B-Active Plus. Research on individual ingredients does not necessarily reflect the effect of the full formula. When study doses differ from B-Active Plus, we note it. Not intended to diagnose, treat, cure, or prevent any disease.

Riboflavin-5-Phosphate (20 mg/day)
 Studied for: cofactor in MTHFR and B6 activation; supports folate recycling and homocysteine metabolism in one-carbon pathways.nutritionalassessment+2
Dose note: RCTs use 20-400 mg/day equivalents. Formula: 20 mg/day. (NIH ODS)
Further reading:
Riboflavin status and B6 (PubMed, 2020): PubMed
 Principles of Nutritional Assessment: Nutritional Assessment

Pyridoxal-5-Phosphate (Vitamin B6, 50 mg/day)
 Studied for: reductions in PMS symptoms (depression, irritability, overall severity); neurotransmitter synthesis and homocysteine transsulfuration.pubmed.ncbi.nlm.nih+2
Dose note: PMS RCTs typically 50-100 mg/day. Formula: 50 mg/day. (JAMA Meta-analysis)
Further reading:
Wyatt et al., 1999 (meta-analysis, 9 RCTs): PMC
 Doll et al., 1989 (RCT, 50 mg/day PMS): PubMed

L-5-Methyltetrahydrofolate (340 mcg DFE/day)
 Studied for: homocysteine reduction, especially in MTHFR variants; superior bioavailability vs folic acid in some genotypes.pmc.ncbi.nlm.nih+2
Dose note: Homocysteine RCTs use 400-800 mcg DFE. Formula: 340 mcg DFE. (PMC RCT)
Further reading:
Pavone et al., 2024 (RCT polymorphisms): PMC
 Active Folate Review (2021): PMC

Methylcobalamin (Vitamin B12, 150 mcg/day)
 Studied for: homocysteine lowering with folate; better tissue retention vs cyanocobalamin in models; neurological support.pmc.ncbi.nlm.nih+2
Dose note: Trials use 150-1,000 mcg/day. Formula: 150 mcg/day. (PMC Bioavailability)
Further reading:
Comparative Bioavailability Review (2016): PMC
 Methylcobalamin Efficacy (2021): PMC

B-Complex Blend (Thiamin 50 mg, Niacin 50 mg, Pantothenic Acid 125 mg, Biotin 1,000 mcg/day)
 Studied for: exercise endurance, fatigue reduction, stress-related mood/strain improvements.medsci+2
Dose note: RCTs use comparable high-dose blends. Formula: as shown. (Int J Med Sci RCT)
Further reading:
Lin et al., 2023 (B-complex endurance RCT): Int J Med Sci
 Stough et al., 2011 (90-day stress RCT): Wiley

Choline Bitartrate (50 mg choline/day)
 Studied for: liver function, PEMT pathway (estrogen-modulated); homocysteine via betaine precursor.pmc.ncbi.nlm.nih+2
Dose note: AI 425-550 mg/day; formula provides foundational 50 mg. (PMC Review)
Further reading:
Zeisel et al., 2012 (choline liver review): PMC
 Estrogen-choline RCT (2010): PMC

Betaine Anhydrous (TMG, 200 mg/day)
 Studied for: homocysteine reduction via BHMT pathway; methylation support.pmc.ncbi.nlm.nih+2
Dose note: Meta-analyses use 4-6 g/day; formula: nutritional 200 mg. (PMC Meta)
Further reading:
Olthof et al., 2003 (meta-analysis): PMC
 Low-dose B+betaine RCT (2023): PubMed

References and full PDFs available upon request. Structure/function claims supported by cited peer-reviewed RCTs and meta-analyses.drbrightenessentials+1

30-Day Guarantee

Try B-Active Plus for 30 days. If it’s not the right fit, contact our team for guidance on next steps.

FAQ

How long does one bottle last?

Each bottle contains 30 capsules and lasts 30 days when taken as directed.

When should I take it?

Take one capsule in the morning with food. Avoid late evening use if you are sensitive to energizing nutrients.

Can I take it every day?

Yes, it is designed for daily foundational support.

Can I take it with coffee or other supplements?

Yes. It pairs well with most supplement protocols. Take with food to support absorption.

Is this safe if I am trying to conceive, pregnant, or nursing?

Consult your clinician before use during pregnancy or nursing.

What if I have a sensitive stomach?

Take with a full meal. If needed, begin every other day before increasing to daily use.

Who is this not for?

Individuals under medical treatment, those with known B-vitamin sensitivities, or anyone managing a health condition should consult a clinician first.

Pairs well with

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