Saw Palmetto Plus provides saw palmetto extract, nettle root, and synergistic hormone-supporting cofactors/antioxidants at doses contributing to a multi-nutrient prostate, androgen, and hair-health matrix. Note: Individual ingredient RCTs typically evaluate single agents at higher doses than in multi-ingredient formulas.
*These studies explore outcomes related to individual ingredients used in Saw Palmetto Plus. Research on individual ingredients does not necessarily reflect the effect of the full formula. When study doses differ from Saw Palmetto Plus, we note it. Not intended to diagnose, treat, cure, or prevent any disease.
Saw Palmetto Extract (450 mg/day, 45% fatty acids)
Studied for: 5α-reductase inhibition, DHT reduction, LUTS/BPH symptom relief (IPSS, nocturia, peak flow), and androgenetic alopecia (reduced shedding, improved density).pmc.ncbi.nlm.nih+4
Dose note: RCTs typically 320–400 mg/day standardized lipidosterolic extract. Formula: 450 mg/day. (PMC)
Further reading:
Prager et al., 2002 RCT (SP + β-sitosterol, AGA): PubMed
Evron et al., 2023 RCT (VISPO oral/topical, AGA): PMC
Bent et al., 2006 meta-analysis (BPH): PubMed
Tacklind et al., 2012 meta-analysis (BPH): PMC
Nettle Root Extract (250 mg/day, 0.8% β-sitosterol)
Studied for: SHBG-receptor interference, BPH symptom relief (IPSS, peak flow, prostate volume), and urinary function.thieme-connect+3
Dose note: RCTs typically 300–600 mg/day. Formula: 250 mg/day. (PubMed)
Further reading:
Safarinejad, 2005 RCT (620 men, 18 months): PubMed
Sayhan et al., 2013 RCT: PMC
Azimi et al., 2016 meta-analysis (5 RCTs): JATCM
Glycine, Alanine, Glutamic Acid (100 mg each/day)
Studied for: BPH symptom relief (nocturia, urgency, frequency, residual urine).pubmed.ncbi.nlm.nih+2
Dose note: Historic trials used 2.3–7 g/day combo. Formula: 100 mg each (low dose). (PubMed)
Further reading:
Feinblatt & Gant, 1958 controlled trial: PubMed
Damrau review (multiple studies): Semantic Scholar
Zinc (10 mg/day)
Studied for: testosterone maintenance, acne lesion reduction, and DHT metabolism support.pmc.ncbi.nlm.nih+2
Dose note: Acne RCTs use 30–90 mg/day. Formula: 10 mg/day. (PMC)
Further reading:
Tezval et al., 2023 systematic review (testosterone): ScienceDirect
Jaffary et al., acne review: PMC
Vitamin D (25 µg/day)
Studied for: association with androgenetic alopecia severity and hair follicle cycling support.onlinelibrary.wiley+2
Dose note: Observational; interventional trials emerging. Formula: 25 µg/day. (Wiley)
Further reading:
Rasheed et al., 2020 case-control: Wiley
Dhurat et al., 2024 case-control: IJORD
Diindolylmethane (DIM, 100 mg/day)
Studied for: favorable estrogen metabolite ratios (↑2-OHE1/↓16-OHE1) and reduced total estrogens.pmc.ncbi.nlm.nih+1
Dose note: RCTs 100–300 mg/day. Formula: 100 mg/day. (PMC)
Further reading:
Zeligs et al., 2010 RCT: PMC
Zeligs et al., 2025 cohort (1,458 women): PMC
Lycopene (20 mg/day)
Studied for: prostate oxidative stress reduction and BPH symptom support in combinations.iomcworld+2
Dose note: Trials 15–30 mg/day. Formula: 20 mg/day. (AACR)
Further reading:
Schwartz et al., 2012 phase II RCT: AACR
Morgia et al., 2014 combo RCT: PubMed
Chrysin (100 mg/day)
Studied for: in vitro aromatase inhibition; limited human bioavailability data.arabjchem+1
Dose note: Human trials lacking due to poor absorption. Formula: 100 mg/day. (Arab J Chem)
Further reading:
Comprehensive review (2026): Arab J Chem
Vitamin B6 (10 mg/day) Studied for: cofactor in steroid hormone metabolism and receptor modulation.pmc.ncbi.nlm.nih+1 Dose note: Mechanistic; clinical RCTs in broader B-complexes. Formula: 10 mg/day. (PMC) Further reading: Majchrzak et al., 2018 review: PMC