What the Research Shows: Clinical Evidence Summary
N-Acetyl Cysteine (NAC) provides 700 mg per capsule as a glutathione precursor and antioxidant with anti-inflammatory and immune-modulating activity. Note: Individual RCTs typically evaluate NAC at 600–1,800 mg/day (often divided), higher than the single-capsule serving but within average exposure for intermittent regimens used in endometriosis trials.
*These studies explore outcomes related to NAC used in clinical research. Research on NAC does not necessarily reflect the effect of multi-ingredient formulas. When study doses differ from this product, we note it. Not intended to diagnose, treat, cure, or prevent any disease.
N-Acetyl Cysteine (700 mg/capsule)
Studied for: endometriosis-related pain/cyst size, PCOS ovulation/fertility, SLE disease activity, and oxidative stress/inflammatory biomarkers (multiple RCTs and meta-analyses).onlinelibrary.wiley+5
Dose note: RCTs typically 600–1,800 mg/day (e.g., 600 mg TID 3 days/week ≈770 mg/day average for endometriosis); SLE trials 1,800–2,400 mg/day. Product: 700 mg/day. (PMC Endometriosis Cohort)
Further reading:
Porpora et al., 2013 (observational cohort): PMC
Rossi et al., 2023 (prospective cohort): PMC
Thawani et al., 2015 (PCOS meta-analysis): Wiley Online
Lai et al., 2012 (SLE RCT): Wiley Online
Omidian et al., 2023 (SLE RCT): PMC
Asbaghi et al., 2021 (inflammation meta-analysis): ScienceDirect
Systematic review on human health impacts (trials through 2021): PMC
Endometriosis Symptom Support
Studied for: reduced dysmenorrhea/dyspareunia/chronic pelvic pain, smaller endometrioma growth, lower CA-125, and higher pregnancy rates (cohort studies).pmc.ncbi.nlm.nih+1
Dose note: 600 mg TID, 3 days/week (~1,800 mg on treatment days). Product: 700 mg/day. (PMC)
Further reading:
Porpora et al., 2013 (92 women): cyst diameter -1.5 mm vs +6.6 mm control; pain ↓50–59%; 24 avoided surgery PMC
Rossi et al., 2023 (120 women): VAS pain ↓~2 points each symptom; cyst size 36.5→33 mm; 75% spontaneous pregnancy PMC
PCOS Fertility Support
Studied for: higher ovulation, clinical pregnancy, and live birth rates vs placebo (8 RCTs, n=910).[onlinelibrary.wiley]
Dose note: 600–1,800 mg/day. Product: 700 mg/day. (Wiley Online)
Further reading:
Thawani et al., 2015 meta-analysis: NAC ↑odds of ovulation/pregnancy vs placebo Wiley Online
Jamilian et al., 2017 (RCT): NAC + clomiphene ↑ovulation in PCOS PMC
Autoimmunity (SLE) Support
Studied for: ↓SLEDAI/BILAG scores, multi-organ improvements, ↑CH50 (RCTs).onlinelibrary.wiley+1
Dose note: 1,800–2,400 mg/day. Product: 700 mg/day. (PMC)
Further reading:
Lai et al., 2012 (RCT, n=36): ≥2.4 g/day ↓SLEDAI P=0.0007–0.0046 Wiley Online
Omidian et al., 2023 (RCT, n=80): 1.8 g/day ↓SLEDAI P=0.034, BILAG P=0.023 PMC
Inflammation/Oxidative Stress Biomarkers
Studied for: ↓MDA, IL-8, homocysteine; subgroup ↓TNF-α/IL-6 (28 trials meta-analysis).[sciencedirect]
Dose note: 600–1,200 mg/day. Product: 700 mg/day. (ScienceDirect)
Further reading:
Asbaghi et al., 2021 meta-analysis: consistent biomarker reductions ScienceDirect
De Flora et al., 2021 review: glutathione/GSH replenishment mechanisms PMC
Thyroid Hormone Modulation Studied for: attenuated T3 decline in acute stress/NTIS (small RCT).[pmc.ncbi.nlm.nih] Dose note: 1,200 mg IV q12h acute. Product: 700 mg/day oral. (PMC) Further reading: Başkal et al., 2013 (RCT post-MI, n=67): NAC preserved T3 at 12h P=0.045 PMC